NFL Week 5 Odds, Spreads and Betting Preview

Mark Fordham
By Mark Fordham
 |  3 mins
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NFL Week 5 Odds, Spreads and Betting Preview

With four weeks in the books, we look ahead to the fifth week of the NFL season and which teams you could look to back at NFL betting sites.

Bookmakers.com is here to guide you through the odds and market lines ahead of Week 5 of the regular season, so you can make the best possible NFL picks at NFL betting apps.

Indianapolis Colts @ Denver Broncos - 20:15 ET Oct. 6

Odds for this game will appear here when available.

Denver Broncos vs Indianapolis Colts
October 6th 8:15pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Indianapolis Colts +2.5 Indianapolis Colts +2.5
52.38%
--
--
-110 1.91 10/11
--
--
Denver Broncos -2.5 Denver Broncos -2.5
52.38%
--
--
-110 1.91 10/11
--
--
Indianapolis Colts Indianapolis Colts
45.45%
--
--
+120 2.20 6/5
--
--
Denver Broncos Denver Broncos
58.34%
--
--
-140 1.71 5/7
--
--
Over 43
52.38%
--
--
-110 1.91 10/11
--
--
Under 43
52.38%
--
--
-110 1.91 10/11
--
--
Over 42.5
--
--
--
--
--
--
Under 42.5
--
--
--
--
--
--
Team Best Odds
Indianapolis Colts +2.5 Indianapolis Colts +2.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Denver Broncos -2.5 Denver Broncos -2.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Indianapolis Colts Indianapolis Colts
+120 2.20 6/5 DraftKings
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+120 2.20 6/5 DraftKings
Denver Broncos Denver Broncos
-140 1.71 5/7 DraftKings
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-140 1.71 5/7 DraftKings
Over 43
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Under 43
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Over 42.5
--
Under 42.5
--
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With new starting quarterbacks for each of the Indianapolis Colts and Denver Broncos, expectations were high heading into the season, but things haven't gone completely to plan.

New York Giants @ Green Bay Packers - 09:30 ET Oct. 9

Odds for this game will appear here when available.

Green Bay Packers vs New York Giants
October 9th 9:30am
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
New York Giants +7.5 New York Giants +7.5
52.38%
--
--
-110 1.91 10/11
--
--
Green Bay Packers -7.5 Green Bay Packers -7.5
52.38%
--
--
-110 1.91 10/11
--
--
New York Giants New York Giants
26.32%
--
--
+280 3.80 14/5
--
--
Green Bay Packers Green Bay Packers
77.28%
--
--
-340 1.29 2/7
--
--
Over 41
52.38%
--
--
-110 1.91 10/11
--
--
Under 41
52.38%
--
--
-110 1.91 10/11
--
--
Over 40.5
--
--
--
--
--
--
Under 40.5
--
--
--
--
--
--
Team Best Odds
New York Giants +7.5 New York Giants +7.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Green Bay Packers -7.5 Green Bay Packers -7.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
New York Giants New York Giants
+280 3.80 14/5 DraftKings
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+280 3.80 14/5 DraftKings
Green Bay Packers Green Bay Packers
-340 1.29 2/7 DraftKings
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-340 1.29 2/7 DraftKings
Over 41
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Under 41
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Over 40.5
--
Under 40.5
--
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The New York Giants haven't reached the postseason since 2016 but hopes are high that this could be the season they turn that record around. The Green Bay Packers have only missed the playoffs three times in the last 15 seasons and won't want to add to that number in 2022.

Houston Texans @ Jacksonville Jaguars - 13:00 ET Oct. 9

Odds for this game will appear here when available.

Jacksonville Jaguars vs Houston Texans
October 9th 1:00pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Houston Texans +7 Houston Texans +7
53.48%
--
--
-115 1.87 13/15
--
--
Jacksonville Jaguars -7 Jacksonville Jaguars -7
51.23%
--
--
-105 1.95 20/21
--
--
Houston Texans Houston Texans
28.99%
--
--
+245 3.45 5/2
--
--
Jacksonville Jaguars Jacksonville Jaguars
74.68%
--
--
-295 1.34 1/3
--
--
Over 43.5
52.38%
--
--
-110 1.91 10/11
--
--
Under 43.5
52.38%
--
--
-110 1.91 10/11
--
--
Team Best Odds
Houston Texans +7 Houston Texans +7
-115 1.87 13/15 DraftKings
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-115 1.87 13/15 DraftKings
Jacksonville Jaguars -7 Jacksonville Jaguars -7
-105 1.95 20/21 DraftKings
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-105 1.95 20/21 DraftKings
Houston Texans Houston Texans
+245 3.45 5/2 DraftKings
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+245 3.45 5/2 DraftKings
Jacksonville Jaguars Jacksonville Jaguars
-295 1.34 1/3 DraftKings
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-295 1.34 1/3 DraftKings
Over 43.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Under 43.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
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The Jacksonville Jaguars and Houston Texans were the cellar-dwellers of the AFC South last season but will hope for improvement come the end of 2022.

Chicago Bears @ Minnesota Vikings - 13:00 ET Oct. 9

Odds for this game will appear here when available.

Minnesota Vikings vs Chicago Bears
October 9th 1:00pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Chicago Bears +7 Chicago Bears +7
--
--
--
--
--
--
Chicago Bears +6.5 Chicago Bears +6.5
52.38%
--
--
-110 1.91 10/11
--
--
Minnesota Vikings -6.5 Minnesota Vikings -6.5
52.38%
--
--
-110 1.91 10/11
--
--
Minnesota Vikings -7 Minnesota Vikings -7
--
--
--
--
--
--
Chicago Bears Chicago Bears
30.30%
--
--
+230 3.30 23/10
--
--
Minnesota Vikings Minnesota Vikings
73.31%
--
--
-275 1.36 4/11
--
--
Over 43
52.38%
--
--
-110 1.91 10/11
--
--
Under 43
52.38%
--
--
-110 1.91 10/11
--
--
Team Best Odds
Chicago Bears +7 Chicago Bears +7
--
Chicago Bears +6.5 Chicago Bears +6.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Minnesota Vikings -6.5 Minnesota Vikings -6.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Minnesota Vikings -7 Minnesota Vikings -7
--
Chicago Bears Chicago Bears
+230 3.30 23/10 DraftKings
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+230 3.30 23/10 DraftKings
Minnesota Vikings Minnesota Vikings
-275 1.36 4/11 DraftKings
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-275 1.36 4/11 DraftKings
Over 43
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Under 43
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
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Year two of the Justin Fields era under a new head coach was supposed to signal better times for the Chicago Bears, but that hasn't quite translated yet. The Minnesota Vikings, also under a new coach, won both games against their NFC North rivals last season.

Los Angeles Chargers @ Cleveland Browns - 13:00 ET Oct. 9

Odds for this game will appear here when available.

Cleveland Browns vs Los Angeles Chargers
October 9th 1:00pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Los Angeles Chargers -1.5 Los Angeles Chargers -1.5
52.38%
--
--
-110 1.91 10/11
--
--
Cleveland Browns +1.5 Cleveland Browns +1.5
52.38%
--
--
-110 1.91 10/11
--
--
Los Angeles Chargers Los Angeles Chargers
55.56%
--
--
-125 1.80 4/5
--
--
Cleveland Browns Cleveland Browns
48.78%
--
--
+105 2.05 21/20
--
--
Over 48
52.38%
--
--
-110 1.91 10/11
--
--
Under 48
52.38%
--
--
-110 1.91 10/11
--
--
Team Best Odds
Los Angeles Chargers -1.5 Los Angeles Chargers -1.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Cleveland Browns +1.5 Cleveland Browns +1.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Los Angeles Chargers Los Angeles Chargers
-125 1.80 4/5 DraftKings
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-125 1.80 4/5 DraftKings
Cleveland Browns Cleveland Browns
+105 2.05 21/20 DraftKings
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+105 2.05 21/20 DraftKings
Over 48
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Under 48
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
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The Cleveland Browns and Los Angeles Chargers are two of the upstart AFC teams looking to make some noise deep into the playoffs in 2022.

Atlanta Falcons @ Tampa Bay Buccaneers - 13:00 ET Oct. 9

Odds for this game will appear here when available.

Tampa Bay Buccaneers vs Atlanta Falcons
October 9th 1:00pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Atlanta Falcons +9 Atlanta Falcons +9
52.38%
--
--
-110 1.91 10/11
--
--
Atlanta Falcons +8.5 Atlanta Falcons +8.5
--
--
--
--
--
--
Tampa Bay Buccaneers -8.5 Tampa Bay Buccaneers -8.5
--
--
--
--
--
--
Tampa Bay Buccaneers -9 Tampa Bay Buccaneers -9
52.38%
--
--
-110 1.91 10/11
--
--
Atlanta Falcons Atlanta Falcons
23.26%
--
--
+330 4.30 33/10
--
--
Tampa Bay Buccaneers Tampa Bay Buccaneers
80.39%
--
--
-410 1.24 4/17
--
--
Over 47.5
52.38%
--
--
-110 1.91 10/11
--
--
Under 47.5
52.38%
--
--
-110 1.91 10/11
--
--
Over 47
--
--
--
--
--
--
Under 47
--
--
--
--
--
--
Team Best Odds
Atlanta Falcons +9 Atlanta Falcons +9
-110 1.91 10/11 DraftKings
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Must be 21+ to participate. T&Cs apply.
-110 1.91 10/11 DraftKings
Atlanta Falcons +8.5 Atlanta Falcons +8.5
--
Tampa Bay Buccaneers -8.5 Tampa Bay Buccaneers -8.5
--
Tampa Bay Buccaneers -9 Tampa Bay Buccaneers -9
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Atlanta Falcons Atlanta Falcons
+330 4.30 33/10 DraftKings
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+330 4.30 33/10 DraftKings
Tampa Bay Buccaneers Tampa Bay Buccaneers
-410 1.24 4/17 DraftKings
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-410 1.24 4/17 DraftKings
Over 47.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Under 47.5
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Over 47
--
Under 47
--
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In his age-45 season, Tom Brady is looking to become the oldest winner of the Super Bowl with the Tampa Bay Buccaneers. If he's successful he would break his own record from February 2021. They will expect to beat divisional rivals Atlanta Falcons along the way.

Seattle Seahawks @ New Orleans Saints - 13:00 ET Oct. 9

Odds for this game will appear here when available.

New Orleans Saints vs Seattle Seahawks
October 9th 1:00pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Seattle Seahawks +6 Seattle Seahawks +6
52.38%
--
--
-110 1.91 10/11
--
--
New Orleans Saints -6 New Orleans Saints -6
52.38%
--
--
-110 1.91 10/11
--
--
Seattle Seahawks Seattle Seahawks
32.26%
--
--
+210 3.10 21/10
--
--
New Orleans Saints New Orleans Saints
71.43%
--
--
-250 1.40 2/5
--
--
Over 41
52.38%
--
--
-110 1.91 10/11
--
--
Under 41
52.38%
--
--
-110 1.91 10/11
--
--
Over 40.5
--
--
--
--
--
--
Under 40.5
--
--
--
--
--
--
Team Best Odds
Seattle Seahawks +6 Seattle Seahawks +6
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
New Orleans Saints -6 New Orleans Saints -6
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Seattle Seahawks Seattle Seahawks
+210 3.10 21/10 DraftKings
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+210 3.10 21/10 DraftKings
New Orleans Saints New Orleans Saints
-250 1.40 2/5 DraftKings
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-250 1.40 2/5 DraftKings
Over 41
-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
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-110 1.91 10/11 DraftKings
Over 40.5
--
Under 40.5
--
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Pete Carroll is in season 13 as head coach of the Seattle Seahawks, while Dennis Allen is in season one as head coach of the New Orleans Saints. Will experience tell in what should be a fairly evenly matched game?

Detroit Lions @ New England Patriots - 13:00 ET Oct. 9

Odds for this game will appear here when available.

New England Patriots vs Detroit Lions
October 9th 1:00pm
BetMGM Caesars DraftKings FanDuel PointsBet
 
% Chance
Detroit Lions 0 Detroit Lions 0
52.38%
--
--
-110 1.91 10/11
--
--
Detroit Lions +1 Detroit Lions +1
--
--
--
--
--
--
Detroit Lions +1.5 Detroit Lions +1.5
--
--
--
--
--
--
New England Patriots 0 New England Patriots 0
52.38%
--
--
-110 1.91 10/11
--
--
New England Patriots -1 New England Patriots -1
--
--
--
--
--
--
New England Patriots -1.5 New England Patriots -1.5
--
--
--
--
--
--
Detroit Lions Detroit Lions
52.38%
--
--
-110 1.91 10/11
--
--
New England Patriots New England Patriots
52.38%
--
--
-110 1.91 10/11
--
--
Over 44
52.38%
--
--
-110 1.91 10/11
--
--
Under 44
52.38%
--
--
-110 1.91 10/11
--
--
Over 44.5
--
--
--
--
--
--
Under 44.5
--
--
--
--
--
--
Team Best Odds
Detroit Lions 0 Detroit Lions 0
-110 1.91 10/11 DraftKings
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Must be 21+ to participate. T&Cs apply.
-110 1.91 10/11 DraftKings
Detroit Lions +1 Detroit Lions +1
--
Detroit Lions +1.5 Detroit Lions +1.5
--
New England Patriots 0 New England Patriots 0
-110 1.91 10/11 DraftKings
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-110 1.91